CJC-1295 vs Ipamorelin
Understand how Growth Hormone Releasing Hormone (GHRH) analogues and selective Ghrelin mimetics cooperate to optimize natural growth hormone secretion without pituitary receptor exhaustion.
Secretagogue Comparison Table
| Parameter | CJC-1295 (Mod GRF 1-29) | Ipamorelin |
|---|---|---|
| Compound Class | GHRH Analogue (Growth Hormone Releasing Hormone) | GHRP / Ghrelin Receptor Agonist (Secretagogue) |
| Receptor Target | GHRH-R (Pituitary) | GHS-R1a (Ghrelin Receptor) |
| Half-Life (No DAC) | ~30 minutes (Pulsatile) | ~2 hours |
| Cortisol / Prolactin Impact | Negligible | Near zero (highest selectivity in class) |
| Primary Effect | Amplifies pulse amplitude of endogenous GH | Triggers release of stored GH vesicles |
CJC-1295 Mode of Action
CJC-1295 mimics endogenous GHRH by binding to pituitary somatotrophs, upregulating intracellular cAMP pathways, and priming somatotrophs to synthesize and release growth hormone. It signals the pituitary that a natural GH pulse is occurring.
Ipamorelin Mode of Action
Ipamorelin activates phospholipase C via the GHS-R1a receptor, triggering intracellular calcium release that forces secretory vesicles of GH to fuse with the cell membrane. It acts as the trigger that discharges the primed GH reserves.
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Secretagogue Research FAQs
Why are CJC-1295 and Ipamorelin commonly stacked together?
CJC-1295 (a Growth Hormone Releasing Hormone analogue) and Ipamorelin (a Growth Hormone Secretagogue / Ghrelin mimetic) bind to two distinct pituitary receptors. When co-administered, they produce a synergistic amplification of natural growth hormone pulsatility—releasing 3 to 5 times more GH than either compound can elicit on its own, while preserving natural somatostatin feedback loops.
What is the difference between CJC-1295 with DAC and without DAC?
DAC (Drug Affinity Complex) binds to serum albumin in the bloodstream, extending the half-life of CJC-1295 from ~30 minutes to approximately 6–8 days, producing continuous GH elevation. CJC-1295 without DAC (also known as Mod GRF 1-29) has a 30-minute half-life, mirroring the body's natural, healthy nocturnal GH pulses without desensitizing pituitary receptors.
Does Ipamorelin raise cortisol, prolactin, or appetite?
Unlike earlier GHRPs (such as GHRP-2, GHRP-6, or Hexarelin), Ipamorelin is ultra-selective for the ghrelin/GHS-R1a receptor. It stimulates endogenous growth hormone release without significantly elevating plasma cortisol, aldosterone, or prolactin, and produces minimal appetite stimulation.
How should CJC-1295 and Ipamorelin be stored after reconstitution?
Both compounds should be reconstituted with sterile Bacteriostatic Water (0.9% benzyl alcohol) and maintained strictly at 2°C–8°C in a dark refrigerator. Lyophilized powders remain stable at -20°C for up to 24 months.