TB-500
Synthetic Thymosin Beta-4 Fragment Studied for Cell Migration & Repair
Written by
Dr. Elena Rostova · Ph.D. Biochemistry
Medical review
Dr. Marcus Vance · PharmD, RPh
Last reviewed
August 15, 2026
About the Author
Dr. Elena Rostova · Ph.D. Biochemistry
Lead Research Scientist & Science Editor
Molecular biochemist and peptide researcher with expertise in solid-phase peptide synthesis (SPPS), HPLC purity verification, and mass spectrometry characterization. Directs literature compilation and scientific dossier synthesis at BioPeptide.
About the Reviewer
Dr. Marcus Vance · PharmD, RPh
Medical & Pharmacology Reviewer
Clinical pharmacist and pharmacokinetics consultant specializing in peptide pharmacology, receptor signaling, and preclinical safety data. Focuses on rigorous evaluation of published biochemical literature, receptor kinetics, and study methodology.
Overview
TB-500 is a synthetic peptide based on the active region of Thymosin Beta-4, a protein naturally present in nearly all human and animal cells. Research interest centers on its proposed role in regulating actin — a protein essential to cell structure and movement — which may influence how cells migrate toward sites of injury.
Proposed Mechanism
Thymosin Beta-4 is known to bind actin monomers, a process implicated in cell motility, blood-vessel formation, and inflammation regulation. Preclinical studies on TB-500 have explored whether this actin-binding activity translates into measurable effects on wound closure, reduced scar-tissue formation, and recruitment of repair cells — such as progenitor and stem cells — to damaged tissue in animal models.
Research Highlights
- Animal studies have investigated TB-500's influence on wound-healing rates and tissue regeneration following induced injury
- Laboratory research has examined its potential role in modulating inflammation and recruiting progenitor cells in cardiac and skeletal-muscle injury models
- Published studies have explored corneal and dermal wound models to assess re-epithelialization speed
Research Dosing Reference
Rodent injury models (cumulative, multi-week protocols)
Aggregate dosing across study periods; individual administration schedules vary widely between published designs
≈2–6 mg per kg body weight
Figures above are reported ranges from published animal/laboratory studies, summarized for academic reference — not recommendations for human or animal administration.
Reported Research Cycle Lengths
Reference guides commonly cite research cycles of roughly 4 to 6 weeks for Thymosin Beta-4 (TB-500) within tissue-repair- and cellular-recovery-focused literature.
Durations referenced here reflect ranges commonly cited across compound literature and reference guides — summarized for academic comparison only. They are not usage recommendations for humans or animals, and do not substitute for primary source review.
Reconstitution & Volume Calculator
A unit-conversion utility for laboratory use. It converts a vial strength and reconstitution volume into a draw volume — it performs arithmetic only and does not suggest, recommend, or imply an appropriate amount of TB-500 for any purpose.
Concentration
2500.0 mcg/mL
Draw volume
0.100 mL
Syringe reading
10.0 units
For laboratory research reference only — not medical advice, and not a dosing recommendation for human or animal use. "Syringe reading" assumes a standard U-100 (100 units per mL) insulin syringe.
Safety & Compliance Notes
- TB-500 has not been evaluated or approved by the FDA for human therapeutic use
- Reported figures reflect animal-study literature only and must not be interpreted as human dosing guidance
- For laboratory and research applications exclusively — not intended for human or veterinary administration
Primary Research Citations
Directly indexed peer-reviewed studies supporting this compound profile
Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK · Journal of Investigative Dermatology (2003)
PMID: 12859632Goldstein AL, Hannappel E, Kleinman HK · Annals of the New York Academy of Sciences (2012)
PMID: 23157580Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D · Nature (2004)
PMID: 15538371Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR, Riley PR · Nature (2007)
PMID: 17203068
Research Grade · >99% HPLC Verified
Order research-grade TB-500with batch-specific Certificate of Analysis (COA). Synthesized to >99% purity. Orders are typically processed within 1–3 business days of payment confirmation.
This page is provided for educational and research-reference purposes only and does not constitute medical advice, a treatment recommendation, or an endorsement of human use. Always consult primary peer-reviewed literature and a qualified professional before drawing conclusions about any compound. All products referenced are sold strictly for laboratory research — not for human consumption.